...October 30. Then he changed the 0 to a 1 } Then he wrote: Diabetus Ligate pancreatic ducts of dogs. Keep dogs alive till acini degenerate leaving Islets....isolate the internal secretion of these to relieve glycosurea.* It was a deceptively simple idea. The Barron article claimed that blocking the ducts destroyed...

...duct of the organ. He entered the following in his notebook on October 31, 1920: Diabetus [sic] Llgate pancreatic ducts of dog. keep dogs alive till acini...isolate the internal secretion of these to relieve glycosurea. In later years, Banting perpetuated the drama of the moment to establish himself as a lone,...

...pancreas would contain the internal secretion in a relatively uncontaminated state: Diabetus Lígale pancreatic ducts of dog. Keep dogs alive till acini...isolate the internal secretion of these to relieve glycosurea. Banting proposed to demonstrate the relief of "glycosurea" by transplanting parts of that...

...tried he couldn't get to sleep. At 2:00 am Banting sat bolt upright and scribbled in his notebook: "Ligate pancreatic ducts of dog. Keep dogs alive till...isolate the internal secretion of these to relieve glycosurea." He misspelled glycosuria, which referred to glucose in the urine, but that wasn't important....

...the acinar cells, leaving the islet cells intact. Banting wrote in his notebook “Diabetus—Ligate pancreatic ducts of dog. Keep dogs alive till acini...degenerate leaving Islets. Try to isolate the internal secretions of these to relieve glycosurea.” (Banting's original spelling has been retained.) The...

...at the Academy of Medicine in Toronto. In it he writes: "Diabetus. Ligate pancreatic ducts of dogs. Keep dogs alive till acini degenerate leaving Islets....isolate the internal secretion of these to relieve glycosurea." November 1920: Banting approaches Macleod with his idea. In that meeting, Macleod apparently...

...the evening after reading the pancreas paper, Banting jotted the following triplet in his notebook: Diabetus. Ligate pancreatic ducts of dog. Keep dogs...acini degenerate leaving Islets. Try to isolate the mternal secretion of these to relieve glycosurea. Banting proposed the use of ligatures because, in...

...1920 Banting wrote in his notebook: “Diabetus (sic!). Ligate pancreatic ducts of the dog. Keep dog alive till acini degenerate leaving Islets. Try to...isolate the internal secretion of these to relieve glycosurea” ¿16 The technique of pancreatic duct ligation, leading to pancreatic degeneration, was...

...sleepless. In the early morning hours he wrote in his diary, "Ligate pancreatic ducts of dog. Keep dog alive till acini degenerate leaving Islets. Try to isolate the internal secretion of these to reduce glycosurea ." Banting's original idea was essentially to repeat in the laboratory the natural...

...University of Minnesota reported on the results of blockage of the pancreatic ducts by gallstones." Blockage of these ducts, which drain the pancreatic...internal secretion of these to relieve glycosuria.""' Colleagues in London, including Professor FR Miller, head of the university's Department of Physiology,...